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Mammalian Manufacturing

Enzene is the pioneer in fully integrated Continuous manufacturing

  • We have developed several mAb manufacturing processes and manufactured Clinical material for Phase III trials. We have expertise in converting fed-batch to continuous manufacturing to offer huge cost savings to our clients and support their early and late-stage product development.
  • Our commercial manufacturing plant is one of the first of its kind fully continuous manufacturing plant and has the capability of producing 3 to 5 Kg of mAbs in an integrated 30-day process to offer huge cost benefits to our partners.
  • Spread out over 5 acres, the facility has a built-up capacity of 200,000 sq. ft. The facility currently has 2 active mammalian manufacturing suites and can house another 4 suites with similar capabilities.
  • The facility, at peak load, can have the productivity of 150 kg/month. We have some of the best in class equipment for our DS manufacturing suites and an exceptional team supporting our activities.

Flexible Manufacturing to cater to all our client’s needs.

  • Flexibility is a critical factor that most companies look for when they decide to outsource. We understand the requirements of our potential customers and thus our facility also can house single-use 2000L bioreactors and allied equipment.
  • Our continuous platform, also being flexible, can be run as either integrated continuous or upstream and downstream discontinuous. This allows us to be a one-stop solution for all outsourcing needs.
  • At Enzene, we follow a one-team approach, and thus our clients are always welcome to visit and observe at our facility.

The mammalian production facility has the following capabilities:

  • Single-use bioreactors: 50L and 200L (Sartorius).
  • Perfusion system: ATF 4, 6, and 10 (Repligen).
  • Continuous Chromatography System: BioSc (Novasep) and AKTA PCC (GE Healthcare).
  • Seed Expansion: 20L Rocking Bioreactor (Sartorius).
  • Nanofiltration and UF/DF System (Sartorius).
  • Single-Use mixers, Incubators, Biosafety cabinets, and Autoclaves.
  • WFI and Pure steam generator.

Infrastructure

  • Single-use bioreactors: 50L and 200L (Sartorius).
  • Perfusion system: ATF 4, 6, and 10 (Repligen).
  • Continuous Chromatography System: BioSc (Novasep) and AKTA PCC (GE Healthcare).
  • Seed Expansion: 20L Rocking Bioreactor (Sartorius).
  • Nanofiltration and UF/DF System (Sartorius).
  • Single-Use mixers, Incubators, Biosafety cabinets, and Autoclaves.
  • WFI and Pure steam generator.
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